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While the pain in mice models is induced by a viral agent, it is also feasible to observe parallels in humans, with instances of Ca 2+ /CaMKII protein involvement in patients with IC/PBS

This sounds scarier than it isthese are almost always treatable with medication
Mental health can deteriorate as well, with increased anxiety, depression, and behavioral changes potentially linked to heavy metal toxicity

Confirming the significant role of Met35 of A1742 in these observations, when the Met35 residue was substituted by norleucine (as noted above, CH 2 in place of the S-atom of Met), no oxidative damage or neurotoxicity to hippocampal neurons was found (115)

Bartsch C, Bartsch H, Lippert TH, Gupta D
