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Accelerated erythrocyte senescence causes dose-limiting anemia of antimalarial enolase inhibitors Posted on: 31 October 2020 , updated on: 1 November 2020 Preprint posted on 10 October 2020 Hallow-ENO: selectively targeting erythrocyte glycolysis improves antimalarial efficacy and accelerates erythrocyte senescence

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Aug, C., Gam, X., Vergnolle, N., Lluel, P

Warnings: Patients with early Leber's disease (hereditary optic nerve atrophy) may experience severe and rapid optic atrophy when treated with vitamin B12. Additionally, treating severe megaloblastic anemia with vitamin B12 can lead to fatal hypokalemia due to increased erythrocyte potassium requirements