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doi: 10.1038/npp.2009.110

Soluble epoxide hydrolase inhibitor protects against blood-brain barrier dysfunction in a mouse model of type 2 diabetes via the AMPK/HO-1 pathway

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First, only a subset of the tumor-associated vasculature within brain tumors exhibits the fenestrations necessary for NP extravasation, resulting in heterogeneous and often inadequate permeability across the BTB [7]