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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimers disease

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In studies of duloxetine in smoking and nonsmoking psychiatric patients (not directly related to pain relief), serum levels of the drug were lower in smokers than in nonsmokers, suggesting that tobacco smoke components induce drug-metabolizing enzymes (e.g., cytochrome P450 1A2) [108, 109]

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