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Inhibition of vitamin K epoxidase decreases the synthesis of these clotting factors, but the complex has a long half-life (about 14 hours), and it is this half-life that determines how long it takes for the concentration of clotting factors to reach a new steady state and for a drug effect to reflect the average warfarin plasma concentration

[DOI] [PubMed] [Google Scholar] Lu L., Zheng G., Wang M., Wang D., Xia Z

Biochem Cell Biol 70, 422428.CrossRefGoogle ScholarPubMed Nagase, M, Yamamoto, Y, Matsumoto, N, Arai, Y & Hirose, N (2018) Increased oxidative stress and coenzyme Q10 deficiency in centenarians

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