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H.HuangJ.PurcellS.FavaM.RushA
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In concert with the E2 ubiquitin-conjugating enzyme UBCH5a, glutathionylated OTUB1 interacts with SLC7A11 and prevents proteasomal degradation (Figure 4)
Thereby, the intestinal epithelial cells are destroyed, and damage to the intestinal mucosal barrier results in inflammatory bowel disease
The results indicated comparable acute effects of both substances, with a longer duration of action of MDA (8 h) compared with MDMA (6 h) [12]
doi:10.1177/107327480000700211
