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Dietary glycine is rate-limiting for glutathione synthesis and may have broad potential for health protection

The principal mechanism driving AOPPs generation involves the activated myeloperoxidase-H 2 O 2 -chloride system in neutrophils, with myeloperoxidase serving as the sole enzyme capable of generating chlorinated oxidants (Figure 2) ( FIGURE 2 As markers of oxygen-mediated protein damage, AOPPs have been identified as indicators of oxidative protein damage and proinflammatory mediators ( 3.2.2 Advanced glycation end- products Advanced glycation end-products (AGEs) and AOPPs share structural similarities and exert comparable biological effects

doi: 10.1155/2014/545804 [DOI] [PMC free article] [PubMed] [Google Scholar] 155

Conducted comprehensive characterization (particle size, PDI, zeta potential, loading efficiency, leakage and stability profiles)

Ferroptosis is characterized by the depletion of intracellular GSH and decreased activity of GPx4, which in turn results in the accumulation of lipid peroxides and Fe(II)-catalyzed oxidation of lipids by the Fenton reaction and increased ROS formation