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Therefore, exosome-mediated ferroptosis plays a significant role in intercellular communication between macrophages and cancer cells within the tumor microenvironment

With sufficient glutathione present, NAPQI is very quickly metabolized into sulfate and cysteine compounds, which are readily excreted through the kidneys.[ref] However, when it isnt neutralized, NAPQI is highly reactive and can cause oxidative stress and damage to the liver cells, hepatocytes, leading to cell death

Nat Med 25, 620627

K., Mohandas, S

Compound 968 can inhibit the activity of GLS2 and overcome the resistance of cancer cells to selective GLS1 inhibitors, resulting in tumor suppression (Lukey et al., 2019)

Published 2020 Apr 10