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It has been studied for sleep, opioid and alcohol withdrawal, stress, and pain modulation

doi: 10.1128/CMR.15.1.125-144.2002
Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS, CardioGram ATL, Deloukas P, Holm H, Kathiresan S, Konig IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Stewart AF (2015) Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community

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Head-to-head trials show tirzepatide producing 3-5 percentage points greater weight loss at comparable timepoints