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First-in-human study of ABBV-075 (mivebresib), a pan-inhibitor of bromodomain and extra terminal (BET) proteins, in patients (pts) with relapsed/refractory (RR) acute myeloid leukemia (AML): Preliminary data

OGM dissolved in artificial cerebrospinalfluid (CSF: NaCl 147 mM, KCl 2.7 mM, CaCl 1.2 mM) was infused at 10 L/min via microsyringe pump, delivering 4 nmol/kg (10 M solution adjusted for rat CSF volume ~ 25 L/100 g body weight)

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was supported by the National Academy of Scientist Education Program of the National Biomedical Foundation under the sponsorship of the Hungarian Ministry of Culture and Innovation

In 2023, an international, multisociety Delphi consensus updated terminology: Nonalcoholic fatty liver disease (NAFLD) was replaced by metabolic dysfunction-associated steatotic liver disease (MASLD), and nonalcoholic steatohepatitis (NASH) was replaced by metabolic dysfunction-associated steatohepatitis (MASH), under the umbrella of steatotic liver disease (SLD) a change now reflected in major society communications and being incorporated into clinical practice