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doi: 10.1001/archophthalmol.2011.141

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Although ubiquinol has multiple roles in cellular metabolism, it is most known for its ability to shuttle electrons between mitochondrial electron transport chain complexes, driving ATP synthesis via oxidative phosphorylation 47

Separately, in a larger, longer-term prospective Swedish cohort ( n 3236 participants with median follow-up of 214 years), higher plasma levels of ergothioneine were associated with significantly lower risk of coronary disease, cardiovascular mortality and overall mortality (hazard ratios per 1 sd increment of ergothioneine were 085, 079 and 086, respectively) (80)

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The strong gastric emptying delay produces significant nausea and constipation requiring aggressive management, but most users adapt by weeks 12-16 with proper titration