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Formulation science is now recognized as a central bottleneck: rational delivery systems, including nanoemulsions, liposomes, and solid lipid nanoparticles, are required to achieve controlled local concentrations, sustained exposure, and acceptable safety profiles in vivo

and the CRUK UCL City of London Centre Award (CTRQQR-2021\100004C416/A25145)

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These data, together with the three published clinical trials with negative results, do not support treatment with uric acid-lowering drugs in patients with CKD to reduce progression of renal function deterioration

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