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Additionally, alanine is reported to be significantly increased with metformin monotherapy and combined with sulfonylurea, and branched-chain amino acids (valine, leucine, and isoleucine) are increased with metformin therapy (t Hart et al., 2018b)

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Neuroprotective effects of a novel Tetrapeptide SGGY from walnut against H(2)O(2)-stimulated oxidative stress in SH-SY5Y cells: possible involved JNK, p38 and Nrf2 signaling pathways