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194 In addition, adenovirus-mediated gene transfer of wild-type AXIN1 induces HCC cell and CRC cell apoptosis, which is blocked by APC, CTNNB1, or AXIN1 mutations

All reduced aggregation of the respective point-mutant target, with several identified to be effective at reducing aggregation and toxicity in an SH-SY5Y line when incubated with other variants

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The inhibitory synaptic activity was recorded using a high chloride intracellular solution containing (in mM): 126 KCl, 4 NaCl, 1 MgSO 4 , 0.02 CaCl 2 , 0.1 BAPTA, 15 glucose, 5 HEPES, 3 ATP, and 0.1 GTP, pH 7.3 with KOH, 290 mosm/L