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In conclusion, the study robustly demonstrated that FOXO4-DRI selectively eliminates senescent Leydig cells, reduces detrimental SASP factor secretion, improves the testicular microenvironment, and ultimately enhances sperm quality and spermatogenesis in aged mice, positioning it as a promising therapeutic candidate for age-related male infertility [2]
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The Journal of clinical investigation 83 , 12471252, doi: 10.1172/JCI114008 (1989)
Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis
