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Additional translational hurdles include potential drugdrug interactions with antiretroviral therapy, uncertainty in therapeutic timing relative to disease stage, and variability of cognitive endpoints in HAND trials
Copper activates TrkB in cortical neurons in a metalloproteinase-dependent manner

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10.1016/j.lfs.2023.121511 117 WangJ.LiuS.MengX.ZhaoX.WangT.LeiZ.et al (2024)
2013;304(10):C995C1001
