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Chrysin induces caspase-dependent apoptosis in both human and murine melanoma cells through activation of ERK and p38 MAPK signaling pathways (Kim DA

Glutathione/-l-glutamyl-l-cysteinyl-glycine (GSH), the most abundant non-enzymatic antioxidant in human cells, is primarily distributed in the cytoplasm, and can directly react with ROS to eliminate peroxides (100)

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Bioorg Med Chem 16:75167524 [DOI] [PubMed] [Google Scholar] Tarrago T, Kichik N, Segu J, Giralt E (2007) The Natural Product Berberine is a Human Prolyl Oligopeptidase Inhibitor

The analysis revealed that metabolic genes, particularly members of the solute carrier (SLC) family such as SLC25A10, SLC25A1, SLC22A1, SLC7A8, and SLC7A9 exhibited comparatively higher expression in HIV-MNO as compared to the other groups (Fig