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Mild side effects may include dryness, flaking, redness, tightness, or sensitivity, especially in the first 2-4 weeks

Intracellular chloride concentration influences the GABA(A) receptor subunit composition

The benefits of gender-affirming hormone therapy include significantly reducing the risk of suicide and depression, highlighting the importance of a contemplative approach to the management of hormonal therapy after a VTE event

Non-selective MRAs, such as spironolactone, also reduce TLR4-mediated pro-inflammatory cytokine release

Some antidepressants also may be used off-label

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