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It can come from a herniated disc or bone overgrowth in the spine

R., Farshbaf, S., EmadiBaygi, M., TajabadiEbrahimi, M., Jafari, P., & Asemi, Z

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This is particularly relevant to metabolic disorders that have already been associated with modulations of the gut microbiome

Furthermore, functional analysis of altered metagenomes revealed that in healthy skin a number of genes are associated to antioxidant activity, such as glutathione metabolism, protecting UV-exposed skin from ROS and oxidative stress