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In a phase 2 trial, setmelanotide was dosed at 1 mg/24 h SC infusion over 90 days (NCT01749137) ( Table 2 )

Journal of Neuroimmunology

Human CRP levels were measured using a DCRP00B ELISA kit (R&D Systems, Inc., MN, USA)

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Multivariate Analysis of Variance with Newman Keuls post-hoc was performed to compare oxytocin receptor expression in the brain regions of interest between untreated MIA mice and normal C57BL6/J mice groups