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(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field

Better NAD+ levels also support healthy insulin signaling

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(1) This compound has emerged as a significant research tool for investigating the role of NNMT in metabolic regulation, energy expenditure, and cellular energetics

Some sources suggest subcutaneous injection provides more reliable absorption

Disclaimer: This product is strictly for laboratory research use only