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Akkermansia muciniphila supplementation improves PD-1 blockade efficacy in MAFLD-related HCC models by restoring intestinal barrier integrity, lowering LPS and BA metabolite translocation, and reducing suppressive cells (MDSCs, M2 macrophages), thereby enhancing CD8 + T cell infiltration (50)

These changes exacerbate neuronal damage and contribute to the progression of neurodegenerative conditions [10, 11, 66]

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The cocktail suggested included also GSH and its precursor N -acetylcysteine that could avoid the rapid and detrimental loss of the intracellular content of the tripeptide during infection