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M., Wei X., et al

I experienced inflammation in my joints that lasted two days with the first shot

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Notably, treatment of mice with Cockayne syndrome with PARP1 inhibitors or NAD + supplements promoted lifespan extension and ameliorated the severe phenotypes caused by PARP1 hyperactivation, providing strong evidence that the negative consequences downstream of PARP1 activation are mediated by dysregulation of NAD + homeostasis in response to extensive DNA damage and genotoxic stress 33

However, there are some groups of people that may be at a greater risk of vitamin B12 overdose
