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2 Translational potential of neurotrophic factors MS, especially in the progressive disease phase, poses therapeutic challenge as current disease modifying therapies fail to address the complex crosstalk between glial cells, neurons and CNS-infiltrating cells as well as their highly dynamic functions ( Highlighting the functional dynamics of astrocytes, depletion of reactive astrocytes in early neuroinflammation increased disease severity in EAE, while depletion of reactive astrocytes during the chronic disease phase ameliorated disease pathogenesis (129, 130)

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They can be new infections resulting from changes in pathogenic organisms or known infections that spread and re-emerge due to pathogens resistance to treatment [124]