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Furthermore, the threshold effect is consistent with the concept that methionine synthase activity may become saturated beyond a certain B12 concentration [17], explaining the diminishing returns observed at higher levels

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Variable patterns of mRNA transcriptions have also been found which lead to a variable protein phenotype resulting in differences in behaviour and response to drugs and growth factors [71]

Clinicians prescribing AOD-9604 alongside other compounds common in this age group need to reason from mechanism

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