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Alternatively, the more supported hypothesis is that there could be hyper-responsivity of the cholinergic receptors at a hypothalamic level, causing a greater decrease in somatostatin tone, and elevated GH release from the anterior pituitary gland (153)

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The selection of CD38 as a target molecule was a key step in the design of a mAb-mediated therapy for human multiple myeloma (MM)

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Scaled to humans, this supports the 250-500 mcg/day range