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For example, in SDH-deficient tumors, which rely heavily on glycolysis due to TCA cycle impairment, WZB117, a GLUT1 inhibitor, can effectively reduce glucose uptake, decrease intracellular ATP, downregulate glycolytic enzymes, and inhibit tumor growth, making it a promising candidate for enhancing treatment outcomes and sensitizing tumors to other therapies [35]

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Each publication was classified into one of three categories such as research article, review article, or book/book chapter

In contrast, supplementation with the s-EV fraction resulted in similar migration levels in WT and CIP4 KO cells (Supplementary Fig

G6PD is an inherited red blood cell condition that can cause hemolysis with high-dose vitamin C, so screening is recommended before any dose above 25 grams

Weak acids have been previously reported to affect the proton motive force 39,40 , but their effect is highly dependent on the external pH