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The list price for GLP-1s for obesity ranges from $12,000 to $16,000/year [2]

This is true for anyone taking an obesity drug, but is particularly worrying for older adults, who are at risk of frailty and falls

Specific antagonists were given 2 h before glucose at 1,500 nmol kg 1 doses, and tirzepatide was given 1 h before glucose, all by intraperitoneal injection

A careful medical history is essential

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Compared with basal insulin, both tirzepatide 5 mg and tirzepatide 15 mg were associated with increased odds of discontinuation of study medication due to adverse events (ESM Table 3)