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It is also induced during endoplasmic reticulum stress, regulated by the ATF4-CHOP branch of the unfolded protein response, and elicits an apoptotic response 40

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Pancreatitis seen in up to 7% of adults within the first few weeks of treatment necessitates azathioprine discontinuation [142]

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doi: 10.3389/fcimb.2022.945851 29 MaldonadoE.Morales-PisonS.UrbinaF.SolariA