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The histone methyltransferase NSD1 has been identified as having potential therapeutic value by upregulating the H3K36me2 modification, thereby activating the expression of the transcription factor SOX9, which subsequently downregulates the key enzyme for ferroptosis, ACSL4, thus attenuating chondrocyte ferroptosis (170)

VX765, a specific caspase-1 inhibitor, alleviates lung ischemia reperfusion injury by suppressing endothelial pyroptosis and barrier dysfunction

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

Sebastiano Di Bucchianico : Conceptualization, Methodology, Validation, Formal analysis, Writing Review & Editing, Supervision, Project administration, Funding acquisition

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Its being studied for its potential in conditions like depression, chronic fatigue syndrome and brain inflammation