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When a decision has been made to decrease the dose or discontinue therapy in an opioid-dependent patient taking hydrocodone bitartrate and acetaminophen tablets, there are a variety of factors that should be considered, including the total daily dose of opioid (including hydrocodone bitartrate and acetaminophen tablets) the patient has been taking, the duration of treatment, the type of pain being treated, and the physical and psychological attributes of the patient

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Use a repeatable calculation method A simple three-step method keeps the math clean: Convert mg to mcg 5 mg = 5,000 mcg Divide by total volume 5,000 mcg 2.0 ml = 2,500 mcg/ml Divide target dose by concentration 300 mcg 2,500 mcg/ml = 0.12 ml That final number is the draw volume