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Selenium, a micronutrient that modulates cardiovascular health via redox enzymology

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3.1.2 Ferroptosis-related lipid metabolism and RCC The acyl-CoA synthetase family member ACLS3 not only regulates the accumulation of lipid droplets in ccRCC and is essential for tumor growth, but also regulates sensitivity to ferroptosis in a manner dependent on the composition of exogenous fatty acids: both functions are implicated in the treatment of ccRCC (83)

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Of course, GPCRs are not the only receptors that activate intracellular signaling cascades