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However, due to limited safety data, these products should be used under a physician's supervision

AMPK regulates carbohydrate metabolism by increasing GLUT 4-dependent glucose uptake through i ) phosphorylation of the Rab-GTPase-activating proteins AS160/TBC1D1 (60) and ii ) increasing the glycolysis-stimulator fructose-2,6-bisphosphate concentrations through phosphorylation of specific 6-phosphofructose-2-kinase isoforms (61)

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Even though DHA can cross the blood-brain barrier through GLUT1 (Agus et al., 1997), it is not the main pathway through which ascorbate reaches the CNS
