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Another potential issue is diabetic retinopathy, especially in patients with type 2 diabetes who experience rapid changes in blood sugar levels

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Hcy-mediated excitotoxicity can also result from mitochondrial dysfunction and oxidative stress, which are preceded by PARP activation and NAD depletion [67]

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IGF-1R also binds to IGF-2, plays a part in the mitogenic effect of this polypeptide during fetal development[47]