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Gastrointestinal bleeding: Upper gastrointestinal bleeding can result from various conditions such as ulcers, gastritis, esophagitis, Mallory-Weiss syndrome, and stomach cancer, which might lead to black stools

Drug-induced pigmentation of the oral mucosa typically resolves within a few weeks to several months following the discontinuation of the causative agent, although in some cases, the discoloration may persist permanently [10]

In July 2010, the Swedish Medical Products Agency issued a warning against the usage of melanotan II

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