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In this trial, 100 patients with severe TBI were randomly assigned to a zinc supplement or a placebo group and then evaluated for 16 days

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This lack of efficacy may be attributed to the low plasma and sputum concentrations of NTZ and the high plasma protein binding of tizoxanide, the active metabolite of NTZ [80], highlighting the need for further pharmacokinetic optimization and clinical research to better understand its potential role in TB treatment

and the influence of sleep complaints and insomnia on inflammaging and molecular processes of cellular aging