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These results therefore suggest that the E3 ubiquitin ligase activity of MKRN1 is required for DNA damage-induced apoptosis

Additionally, as a hydrophilic molecule, DFO has a poor cell permeability and tends to remain in extracellular fluid, which may still limit its efficacy (Hanson et al., 2009

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[DOI] [PubMed] [Google Scholar] 6.Xin Y, Wang Y, Zhong L, Shi B, Liang H, Han J

Subsequently, identifying ways in which optimal availability of cysteine is achieved has been a primary approach in an effort to maintain the biosynthesis of reduced glutathione