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[DOI] [PubMed] [Google Scholar] 37.Victorelli S, Lagnado A, Halim J, et al

Individuals with Restricted Diets or Poor Appetite: Those with limited food choices, poor appetite, or eating disorders may have difficulty obtaining sufficient B vitamins from their diets

In a first-in-human clinical trial (NCT02491281), LNA043 was administered via intra-articular injection before total knee replacement, and results showed that LNA043 could reverse the transcriptome signature associated with osteoarthritis by promoting the expression of hyaline cartilage matrix components and anabolic signaling pathways [435]

Clinical trials testing the drug on 300 obese patients in Australia once a day for 12 weeks tripled the weight loss compared to a placebo