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Of note, a study using a mouse model of TSC showed that autophagy is prosurvival for TSC tumorigenesis, suggesting that rapamycin or rapalog treatment is not effective, but autophagy inhibition is beneficial for the treatment of TSC (100)

Intracellular ROS accumulation increases unstable iron and lipid peroxidation deposition through AMPK/NCOA4-mediated ferritinophagy, ultimately leading to ferroptosis and dysfunction in rat BMSCs

Subsequently, compound identification is performed via high-accuracy mass matching against reference databases

The glutathione system: A new drug target in neuroimmune disorders

[24] demonstrated that increasing brain magnesium content via supplementation improved synaptic plasticity and spatial learning in rodents, supporting our findings of enhanced memory performance and increased hippocampal BDNF in the Mg-citrate group

doi: 10.1038/s41392-024-02019-4