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Description
Mounting evidence has demonstrated that ferroptosis could be initiated and implemented by assorted intracellular metabolic processes, including amino acid, lipid peroxidation, and iron metabolism (Figure 1)
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There are five criteria for evaluating redox regulation via reversible glutathionylation, S -glutathionylation must (a) be at a discrete site and functionally effective, (b) occur in a high GSH/GSSG ratio, i.e

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10.1096/fj.201902396R 26 ChoiE

Therefore, it is important to be aware that the use of DMSO as a solvent for the substance of our interest (even in amounts generally considered acceptable) may provide an additional source of oxygen atoms, sulfur atoms, or monocarbon units for the various processes normally occurring in the cells [13]
