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The brain tissue is generally rich in unsaturated fatty acids, which are targets of oxidative stress, and has relatively low levels of antioxidants or antioxidant enzymes

However, in a post-hoc analysis, roumilast signicantly reduced the rate of moderate and severe exacerbations in participants with greater than 3 exacerbations per year and/or one or more hospitalizations in the prior year

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Notably, the reduction of L-cystine to L-cysteine consumes one reducing equivalent of NADPH 39

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Insufficient iron can lead to inappropriate escalation of the erythropoiesis-stimulating agent (ESA) dose, which is associated with adverse outcomes
