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3.5.3 Neuronal dysfunction Damage to DRG neurons is a key characteristic of neuropathic pain

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With the development of blastomeres, MT1 receptor expression gradually increases, and it is primarily localized on the cell membrane

Particularly, dysfunction of EAAC1, which is a neuronal transporter for cysteine and glutamate uptake, impairs neuronal GSH synthesis to cause GSH depletion in aging-related neurodegenerative diseases