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Their effects are marked by increased satiety, reduced appetite, and improved metabolic biomarkers, with a safety profile dominated by mild to moderate gastrointestinal adverse events

Markers of oxidative stress Malondialdehyde (MDA) assay The relative MDA concentration was assessed using a Lipid Peroxidation Assay Kit (Abcam, Great Britain, Catalogue number: ab118970) according to the manufacturers instructions

Data and Safety Monitoring Boards The DSMB comprises a paediatrician, public health expert and a biostatistician

Gut 31 , 10371040 (1990)
