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In skeletal muscle of UBE3B KO mice, there is an accumulation of BDK that leads to a decrease in BCKDH complex activity, but this does not correlate with changes in BCAA levels, indicating that BCKAs could be driven to other pathways (Cheon et al., 2019)

It is qualified as "non-essential" because the human body can produce it in sufficient quantity for its basic needs

Association of RAGE gene polymorphisms with type 2 diabetes mellitus, diabetic retinopathy and diabetic nephropathy

4.American Academy of Sleep Medicine