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The gene encoding for the leptin receptor, a class I cytokine receptor, is mutated in fatty (fa/fa) rats and in diabetic (db/db) mice [12]

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The AOD 9604 trials did not report responder rates in the same way, but the modest average effect suggests a much lower percentage of participants experienced noticeable changes

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That way, you can plan your treatment without surprises

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This escalation should only occur if the lower dose is well-tolerated and additional benefit is needed to achieve treatment goals

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