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Post-treatment with quercetin, significant reductions were noted in the expression of IL-6, AKT1, IL-1, and PTGS2, particularly in prostaglandin-endoperoxide synthase 2 (PTGS2) expression, which correlates with increased total Fe, Fe 2+ , MDA, and ROS levels

Minich, D

Protocol [1] A total of two sets of adult male C57BL/6j mice weighing 21-26 g are randomly assigned to one of four groups and treated with intraperitoneal (i.p.) delivery of (i) vehicle (50 L isotonic saline/5% ethanol), (ii) melatonin (4 mg/kg, dissolved in 0.9% isotonic saline/5% ethanol), (iii) Wortmannin, and (iv) melatonin/Wortmannin immediately after reperfusion

- Stop usage and observe

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Jentsch MC, Van Buel EM, Bosker FJ, Gladkevich AV, Klein HC, Oude Voshaar RC, Ruhe EG, Eisel UL, Schoevers RA