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Conclusions Numerous medicinal plants and their bioactive compounds exhibit significant potential in preventing drug-induced ototoxicity through a variety of mechanisms, primarily by addressing oxidative stress and inflammation

Yuen MF, Berliba E, Sukeepaisarnjaroen W, Strasser S, Tangkijvanich P, Holmes J, et al

The second line of defense involves the use of NADPH to reduce GSSG and TrxS2 by TRX, GCL, and glutathione synthetase responsible for GSH synthesis, glutathione reductase, and thioredoxin reductase

Oncogene 44(3):115129 Classen F et al (2019) Autophagy induced by ionizing radiation promotes cell death over survival in human colorectal cancer cells

W., Cheek J., Henshaw T

Zhao, Dai, & Zhou, 2016)
