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Description
Rothman et al., 2011, 2012

NADPH oxidase (NOX), lipoxygenase, cyclooxygenase (COX), xanthine oxidase (XO), uncoupled nitric oxide synthases (NOS), cytochrome P450, and mitochondrial respiration are the most common enzymatic causes of ROS in CVD [11]

These differences determine everything from side effect profiles to which patients respond best to each compound

In chronic plantar fasciitis, this organization becomes disrupted, with collagen fibers losing their alignment and the tissue becoming thickened yet weaker

A capsule sitting in the kitchen cabinet, taken "when I remember," rarely gets a fair test

That does not invalidate the findings, but it is relevant context for how to interpret them [19]
