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However, this and other catecholaminergic cell lines are widely used for toxicological studies at the cellular and molecular levels, due to inherent advantages in relation to primary neuronal culture systems, for instance, the human origin of these cells, high cellular homogeneity (rodent primary dopaminergic culture systems present only 5% of tyrosine hydroxylase-positive cells), and the presence of many biochemical and functional characteristics of neurons that are easily measurable and detectable, such as neurite extension, -III-tubulin, and tyrosine hydroxylase expression, as well as catecholamine production and secretion

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Gastric dysmotility research, gut-brain axis studies, and energy balance models where ghrelins full biological program needs to be active those are the use cases where GHRP-6s breadth is an asset rather than a liability