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Several NADs have entered the clinical trial recently, and some have been approved for therapeutic use in different fields

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Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)

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Moreover, N-acetylcysteine butyl ester (NACBE), a highly lipophilic NAC prodrug, showed a superior effect in increasing the mitochondrial GSH content and protecting against mitochondrial membrane depolarization and ATP loss after an oxidative insult exposure when compared to NAC in human retinal pigment epithelial cells [156]